Selected Publications

Valentine, J., Ahmadian, M., Keinan, O., Abu-Odeh, M., Zhao, P., Zhou, X., Keller, M., Gao, H., Yu, R., Liddle, C., Downes, M., Zhang, J., Lusis, A.J., Attie, A.D., Evans, R.M., Ryden, M., Saltiel, A.R. (2022). β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity. J Clin Invest 2022;132(2):e153357

Dou, H., Kotini, A., Liu, W., Fidler, T., Umeda, K., Sun, X., Olszewska, M., Xiao, T., Abramowicz, S., Yalcinkaya, M., Hardaway, B., Tsimikas, S., Que, X., Bick, A., Emdin, C., Natarajan, P., Papapetrou, E., Witztum, J. L., Wang, N., Tall, A.R. (2021). Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK (SH2B3) Deficiency. Circulation 2021;144:1940-1954

Palmieri, M., Almeida, M., Nookaew, I., Gomez-Acevedo, H., Joseph, T., Que, X., Tsimikas, S., Sun, X., Manolagas, S.C., Witztum, J.L., Ambrogini, E.. (2021). Neutralization of oxidized phospholipids attenuates age-associated bone loss in mice. Aging Cell 2021:e13442

Xu, S., Chaudhary, O., Rodriguez-Morales, P., Sun, X., Zappasodi, R., Xu, Z., Pinto, A., Williams, A., Chen, D., Low, J., Garskoglu, Y., Tang, W., Wang, H., Varanasi, S., McDonald, B., Tripple, V., Downes, M., Evans, R., Abumrad, N., Merghoub, T., Wolchok, J., Shokhirev, M., Ho, P., Witztum, J., Emu, B., Cui, G., Kaech, S. (2021) Oxidized Lipids and CD36-Mediated Lipid Peroxidation in CD8 T Cells Suppress Anti-Tumor Immune Responses. Immunity 54, 1-17

Zhao, P.*#, Sun, X.*, Chaggan, C., Liao, Z., In Wong, K., He, F., Singh, S., Loomba, R., Karin, M., Witztum, J. L., and Saltiel, A. R#. (2020) An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis. Science 367, 652-660. (#co-corresponding authors; *co-first authors)

Recommended by Faculty 1000 Prime

See highlights of our story at:

Sun, X.#, Seidman, J. S., Zhao, P., Troutman, T. D., Spann, N. J., Que, X., Zhou, F., Liao, Z., Pasillas, M., Yang, X., Magida, J. A., Kisseleva, T., Brenner, D. A., Downes, M., Evans, R. M., Saltiel, A. R., Tsimikas, S., Glass, C. K., and Witztum, J. L#. (2020) Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. Cell Metab 31, 189-206 e188. (#co-corresponding authors)

See highlights of our story at:

Seidman, J. S., Troutman, T. D., Sakai, M., Gola, A., Spann, N. J., Bennett, H., Bruni, C. M., Ouyang, Z., Li, R. Z., Sun, X., Vu, B. T., Pasillas, M. P., Ego, K. M., Gosselin, D., Link, V. M., Chong, L. W., Evans, R. M., Thompson, B. M., McDonald, J. G., Hosseini, M., Witztum, J. L., Germain, R. N., and Glass, C. K. (2020) Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis. Immunity 52, 1057-1074 e1057

Reilly, S. M., Hung, C. W., Ahmadian, M., Zhao, P., Keinan, O., Gomez, A. V., DeLuca, J. H., Dadpey, B., Lu, D., Zaid, J., Poirier, B., Peng, X., Yu, R. T., Downes, M., Liddle, C., Evans, R. M., Murphy, A. N., and Saltiel, A. R. (2020) Catecholamines suppress fatty acid re-esterification and increase oxidation in white adipocytes via STAT3. Nat Metab 2, 620-634

Sun, X., Lv, H., Zhao, P., He, J., Cui, Q., Wei, M., Feng, S., and Zhu, Y. (2019) Commutative regulation between endothelial NO synthase and insulin receptor substrate 2 by microRNAs. J Mol Cell Biol 11, 509-520

Zhao, P., Wong, K. I., Sun, X., Reilly, S. M., Uhm, M., Liao, Z., Skorobogatko, Y., and Saltiel, A. R. (2018) TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue. Cell 172, 731-743 e712

See highlights of our story at:

Skorobogatko, Y., Dragan, M., Cordon, C., Reilly, S. M., Hung, C. W., Xia, W., Zhao, P., Wallace, M., Lackey, D. E., Chen, X. W., Osborn, O., Bogner-Strauss, J. G., Theodorescu, D., Metallo, C. M., Olefsky, J. M., and Saltiel, A. R. (2018) RalA controls glucose homeostasis by regulating glucose uptake in brown fat. Proc Natl Acad Sci U S A 115, 7819-7824

Que, X., Hung, M. Y., Yeang, C., Gonen, A., Prohaska, T. A., Sun, X., Diehl, C., Maatta, A., Gaddis, D. E., Bowden, K., Pattison, J., MacDonald, J. G., Yla-Herttuala, S., Mellon, P. L., Hedrick, C. C., Ley, K., Miller, Y. I., Glass, C. K., Peterson, K. L., Binder, C. J., Tsimikas, S., and Witztum, J. L. (2018) Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature 558, 301-306

Kim, J. Y., Garcia-Carbonell, R., Yamachika, S., Zhao, P., Dhar, D., Loomba, R., Kaufman, R. J., Saltiel, A. R., and Karin, M. (2018) ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P. Cell 175, 133-145 e115

Oral, E. A., Reilly, S. M., Gomez, A. V., Meral, R., Butz, L., Ajluni, N., Chenevert, T. L., Korytnaya, E., Neidert, A. H., Hench, R., Rus, D., Horowitz, J. F., Poirier, B., Zhao, P., Lehmann, K., Jain, M., Yu, R., Liddle, C., Ahmadian, M., Downes, M., Evans, R. M., and Saltiel, A. R. (2017) Inhibition of IKKvarepsilon and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes. Cell Metab 26, 157-170 e157

Shentu, T., He, M., Sun, X., Zhang, J., Zhang, F., Gongol, B., Marin, T., Zhang, J., Wen, L., Wang, Y., Geary, G., Zhu, Y., Johnson, D., Shyy, J. (2016) AMP-Activated Protein Kinase and Sirtuin 1 Coregulation of Cortactin Contributes to Endothelial Function. Arterioscler Thromb Vasc Biol 36(12):2358-2368

Sun, X., Fu, Y., Gu, M., Zhang, L., Li, D., Li, H., Chien, S., Shyy, J. Y., and Zhu, Y. (2016) Activation of integrin alpha5 mediated by flow requires its translocation to membrane lipid rafts in vascular endothelial cells. Proc Natl Acad Sci U S A 113, 769-774

Zhao, P., Elks, C. M., and Stephens, J. M. (2014) The induction of lipocalin-2 protein expression in vivo and in vitro. J Biol Chem 289, 5960-5969

Zhao, P., and Stephens, J. M. (2013) Identification of STAT target genes in adipocytes. JAKSTAT 2, e23092

Gu, M. X.*, Fu, Y.*, Sun, X. L.*, Ding, Y. Z., Li, C. H., Pang, W., Pan, S., and Zhu, Y. (2012) Proteomic analysis of endothelial lipid rafts reveals a novel role of statins in antioxidation. J Proteome Res 11, 2365-2373. (*co-first authors)