Selected Publications

• Xia W, Veeragandham P, Cao Y, Xu Y, Rhyne T, Qian J, Hung CW, Zhao P, Jones Y, Gao H, Liddle C, Yu R, Downes M, Evans R, Ryden M, Wabitsch M, Wang Z, Hakozaki H, Schoneberg J, Reilly S, Huang J, Saltiel AR. (2024). Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation. Nature Metabolism 6: 273–289.

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• Valentine, J., Ahmadian, M., Keinan, O., Abu-Odeh, M., Zhao, P., Zhou, X., Keller, M., Gao, H., Yu, R., Liddle, C., Downes, M., Zhang, J., Lusis, A.J., Attie, A.D., Evans, R.M., Ryden, M., Saltiel, A.R. (2022). β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity. J Clin Invest 132(2):e153357 

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• Dou, H.,  Kotini, A.,  Liu, W.,  Fidler, T.,  Umeda, K.,  Sun, X.,  Olszewska, M., Xiao, T.,  Abramowicz, S., Yalcinkaya, M.,  Hardaway, B., Tsimikas, S., Que, X., Bick, A., Emdin, C., Natarajan, P., Papapetrou, E., Witztum, J. L., Wang, N., Tall, A.R. (2021). Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK (SH2B3) Deficiency. Circulation 144:1940-1954 

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• Palmieri, M., Almeida, M., Nookaew, I., Gomez-Acevedo, H., Joseph, T., Que, X., Tsimikas, S., Sun, X., Manolagas, S.C., Witztum, J.L., Ambrogini, E.. (2021). Neutralization of oxidized phospholipids attenuates age-associated bone loss in mice. Aging Cell 20:e13442

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• Xu, S., Chaudhary, O., Rodriguez-Morales, P., Sun, X., Zappasodi, R., Xu, Z., Pinto, A., Williams, A., Chen, D., Low, J., Garskoglu, Y., Tang, W., Wang, H., Varanasi, S., McDonald, B., Tripple, V., Downes, M., Evans, R., Abumrad, N., Merghoub, T., Wolchok, J., Shokhirev, M., Ho, P., Witztum, J., Emu, B., Cui, G., Kaech, S. (2021) Oxidized Lipids and CD36-Mediated Lipid Peroxidation in CD8 T Cells Suppress Anti-Tumor Immune Responses. Immunity 54, 1-17

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• Zhao, P.*#, Sun, X.*, Chaggan, C., Liao, Z., In Wong, K., He, F., Singh, S., Loomba, R., Karin, M., Witztum, J. L., and Saltiel, A. R#. (2020) An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis. Science 367, 652-660. (#co-corresponding authors; *co-first authors)

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      Recommended by Faculty 1000 Prime

      See highlights of our story at:

      Nature Reviews Molecular Cell Biology: http://www.nature.com/articles/s41580-020-0225-0

      Hepatology: https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.31294

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• Zhao, P., and Saltiel, A. R. (2020) Interaction of Adipocyte Metabolic and Immune Functions Through TBK1. Front in Immunol 11:592949

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• Zhao, P., and Saltiel, A. R. (2020) From overnutrition to liver injury: AMP-activated protein kinase in nonalcoholic fatty liver diseases. J Biol Chem 295, 12279-12289​

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• Sun, X.#, Seidman, J. S., Zhao, P., Troutman, T. D., Spann, N. J., Que, X., Zhou, F., Liao, Z., Pasillas, M., Yang, X., Magida, J. A., Kisseleva, T., Brenner, D. A., Downes, M., Evans, R. M., Saltiel, A. R., Tsimikas, S., Glass, C. K., and Witztum, J. L#. (2020) Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. Cell Metab 31, 189-206 e188. (#co-corresponding authors)

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      See highlights of our story at:

      Science Translational Medicine: https://stm.sciencemag.org/content/11/523/eaaz9770

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• Seidman, J. S., Troutman, T. D., Sakai, M., Gola, A., Spann, N. J., Bennett, H., Bruni, C. M., Ouyang, Z., Li, R. Z., Sun, X., Vu, B. T., Pasillas, M. P., Ego, K. M., Gosselin, D., Link, V. M., Chong, L. W., Evans, R. M., Thompson, B. M., McDonald, J. G., Hosseini, M., Witztum, J. L., Germain, R. N., and Glass, C. K. (2020) Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis. Immunity 52, 1057-1074 e1057

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• Reilly, S. M., Hung, C. W., Ahmadian, M., Zhao, P., Keinan, O., Gomez, A. V., DeLuca, J. H., Dadpey, B., Lu, D., Zaid, J., Poirier, B., Peng, X., Yu, R. T., Downes, M., Liddle, C., Evans, R. M., Murphy, A. N., and Saltiel, A. R. (2020) Catecholamines suppress fatty acid re-esterification and increase oxidation in white adipocytes via STAT3. Nat Metab 2, 620-634

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• Sun, X., Lv, H., Zhao, P., He, J., Cui, Q., Wei, M., Feng, S., and Zhu, Y. (2019) Commutative regulation between endothelial NO synthase and insulin receptor substrate 2 by microRNAs. J Mol Cell Biol 11, 509-520

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• Zhao, P., Wong, K. I., Sun, X., Reilly, S. M., Uhm, M., Liao, Z., Skorobogatko, Y., and Saltiel, A. R. (2018) TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue. Cell 172, 731-743 e712

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      See highlights of our story at:

      Nature Reviews Endocrinology: https://www.nature.com/articles/nrendo.2018.23

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• Skorobogatko, Y., Dragan, M., Cordon, C., Reilly, S. M., Hung, C. W., Xia, W., Zhao, P., Wallace, M., Lackey, D. E., Chen, X. W., Osborn, O., Bogner-Strauss, J. G., Theodorescu, D., Metallo, C. M., Olefsky, J. M., and Saltiel, A. R. (2018) RalA controls glucose homeostasis by regulating glucose uptake in brown fat. Proc Natl Acad Sci U S A 115, 7819-7824

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• Que, X., Hung, M. Y., Yeang, C., Gonen, A., Prohaska, T. A., Sun, X., Diehl, C., Maatta, A., Gaddis, D. E., Bowden, K., Pattison, J., MacDonald, J. G., Yla-Herttuala, S., Mellon, P. L., Hedrick, C. C., Ley, K., Miller, Y. I., Glass, C. K., Peterson, K. L., Binder, C. J., Tsimikas, S., and Witztum, J. L. (2018) Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature 558, 301-306

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• Kim, J. Y., Garcia-Carbonell, R., Yamachika, S., Zhao, P., Dhar, D., Loomba, R., Kaufman, R. J., Saltiel, A. R., and Karin, M. (2018) ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P. Cell 175, 133-145 e115

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• Oral, E. A., Reilly, S. M., Gomez, A. V., Meral, R., Butz, L., Ajluni, N., Chenevert, T. L., Korytnaya, E., Neidert, A. H., Hench, R., Rus, D., Horowitz, J. F., Poirier, B., Zhao, P., Lehmann, K., Jain, M., Yu, R., Liddle, C., Ahmadian, M., Downes, M., Evans, R. M., and Saltiel, A. R. (2017) Inhibition of IKKvarepsilon and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes. Cell Metab 26, 157-170 e157

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• Shentu, T., He, M., Sun, X., Zhang, J., Zhang, F., Gongol, B., Marin, T., Zhang, J., Wen, L., Wang, Y., Geary, G., Zhu, Y., Johnson, D., Shyy, J. (2016) AMP-Activated Protein Kinase and Sirtuin 1 Coregulation of Cortactin Contributes to Endothelial Function. Arterioscler Thromb Vasc Biol 36(12):2358-2368

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• Sun, X., Fu, Y., Gu, M., Zhang, L., Li, D., Li, H., Chien, S., Shyy, J. Y., and Zhu, Y. (2016) Activation of integrin alpha5 mediated by flow requires its translocation to membrane lipid rafts in vascular endothelial cells. Proc Natl Acad Sci U S A 113, 769-774

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• Zhang, D., Sun, X., Liu, J., Xie, X., Cui, W., Zhu, Y. (2015) Homocysteine accelerates senescence of endothelial cells via DNA hypomethylation of human telomerase reverse transcriptase. Arterioscler Thromb Vasc Biol 35(1):71-8

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• Zhao, P., Elks, C. M., and Stephens, J. M. (2014) The induction of lipocalin-2 protein expression in vivo and in vitro. J Biol Chem 289, 5960-5969

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• Zhao, P., and Stephens, J. M. (2013) STAT1, NF-kappaB and ERKs play a role in the induction of lipocalin-2 expression in adipocytes. Mol Metab 2, 161-170

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• Zhao, P., and Stephens, J. M. (2013) Identification of STAT target genes in adipocytes. JAKSTAT 2, e23092

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• Gu, M. X.*, Fu, Y.*, Sun, X. L.*, Ding, Y. Z., Li, C. H., Pang, W., Pan, S., and Zhu, Y. (2012) Proteomic analysis of endothelial lipid rafts reveals a novel role of statins in antioxidation. J Proteome Res 11, 2365-2373. (*co-first authors)