







Selected Publications
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Dou, H., Kotini, A., Liu, W., Fidler, T., Umeda, K., Sun, X., Olszewska, M., Xiao, T., Abramowicz, S., Yalcinkaya, M., Hardaway, B., Tsimikas, S., Que, X., Bick, A., Emdin, C., Natarajan, P., Papapetrou, E., Witztum, J. L., Wang, N., Tall, A.R. (2021). Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK (SH2B3) Deficiency. Circulation 2021;144:1940-1954
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Palmieri, M., Almeida, M., Nookaew, I., Gomez-Acevedo, H., Joseph, T., Que, X., Tsimikas, S., Sun, X., Manolagas, S.C., Witztum, J.L., Ambrogini, E.. (2021). Neutralization of oxidized phospholipids attenuates age-associated bone loss in mice. Aging Cell 2021:e13442
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Xu, S., Chaudhary, O., Rodriguez-Morales, P., Sun, X., Zappasodi, R., Xu, Z., Pinto, A., Williams, A., Chen, D., Low, J., Garskoglu, Y., Tang, W., Wang, H., Varanasi, S., McDonald, B., Tripple, V., Downes, M., Evans, R., Abumrad, N., Merghoub, T., Wolchok, J., Shokhirev, M., Ho, P., Witztum, J., Emu, B., Cui, G., Kaech, S. (2021) Oxidized Lipids and CD36-Mediated Lipid Peroxidation in CD8 T Cells Suppress Anti-Tumor Immune Responses. Immunity 54, 1-17
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Zhao, P.*#, Sun, X.*, Chaggan, C., Liao, Z., In Wong, K., He, F., Singh, S., Loomba, R., Karin, M., Witztum, J. L., and Saltiel, A. R#. (2020) An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis. Science 367, 652-660. (#co-corresponding authors; *co-first authors)
Recommended by Faculty 1000 Prime
See highlights of our story at:
Nature Reviews Molecular Cell Biology: http://www.nature.com/articles/s41580-020-0225-0
Hepatology: https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.31294
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Zhao, P., and Saltiel, A. R. (2020) Interaction of Adipocyte Metabolic and Immune Functions Through TBK1. Front in Immunol 11:592949
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Zhao, P., and Saltiel, A. R. (2020) From overnutrition to liver injury: AMP-activated protein kinase in nonalcoholic fatty liver diseases. J Biol Chem 295, 12279-12289
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Sun, X.#, Seidman, J. S., Zhao, P., Troutman, T. D., Spann, N. J., Que, X., Zhou, F., Liao, Z., Pasillas, M., Yang, X., Magida, J. A., Kisseleva, T., Brenner, D. A., Downes, M., Evans, R. M., Saltiel, A. R., Tsimikas, S., Glass, C. K., and Witztum, J. L#. (2020) Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. Cell Metab 31, 189-206 e188. (#co-corresponding authors)
See highlights of our story at:
Science Translational Medicine: https://stm.sciencemag.org/content/11/523/eaaz9770
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Seidman, J. S., Troutman, T. D., Sakai, M., Gola, A., Spann, N. J., Bennett, H., Bruni, C. M., Ouyang, Z., Li, R. Z., Sun, X., Vu, B. T., Pasillas, M. P., Ego, K. M., Gosselin, D., Link, V. M., Chong, L. W., Evans, R. M., Thompson, B. M., McDonald, J. G., Hosseini, M., Witztum, J. L., Germain, R. N., and Glass, C. K. (2020) Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis. Immunity 52, 1057-1074 e1057
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Reilly, S. M., Hung, C. W., Ahmadian, M., Zhao, P., Keinan, O., Gomez, A. V., DeLuca, J. H., Dadpey, B., Lu, D., Zaid, J., Poirier, B., Peng, X., Yu, R. T., Downes, M., Liddle, C., Evans, R. M., Murphy, A. N., and Saltiel, A. R. (2020) Catecholamines suppress fatty acid re-esterification and increase oxidation in white adipocytes via STAT3. Nat Metab 2, 620-634
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Sun, X., Lv, H., Zhao, P., He, J., Cui, Q., Wei, M., Feng, S., and Zhu, Y. (2019) Commutative regulation between endothelial NO synthase and insulin receptor substrate 2 by microRNAs. J Mol Cell Biol 11, 509-520
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Zhao, P., Wong, K. I., Sun, X., Reilly, S. M., Uhm, M., Liao, Z., Skorobogatko, Y., and Saltiel, A. R. (2018) TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue. Cell 172, 731-743 e712
See highlights of our story at:
Nature Reviews Endocrinology: https://www.nature.com/articles/nrendo.2018.23
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Skorobogatko, Y., Dragan, M., Cordon, C., Reilly, S. M., Hung, C. W., Xia, W., Zhao, P., Wallace, M., Lackey, D. E., Chen, X. W., Osborn, O., Bogner-Strauss, J. G., Theodorescu, D., Metallo, C. M., Olefsky, J. M., and Saltiel, A. R. (2018) RalA controls glucose homeostasis by regulating glucose uptake in brown fat. Proc Natl Acad Sci U S A 115, 7819-7824
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Que, X., Hung, M. Y., Yeang, C., Gonen, A., Prohaska, T. A., Sun, X., Diehl, C., Maatta, A., Gaddis, D. E., Bowden, K., Pattison, J., MacDonald, J. G., Yla-Herttuala, S., Mellon, P. L., Hedrick, C. C., Ley, K., Miller, Y. I., Glass, C. K., Peterson, K. L., Binder, C. J., Tsimikas, S., and Witztum, J. L. (2018) Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature 558, 301-306
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Kim, J. Y., Garcia-Carbonell, R., Yamachika, S., Zhao, P., Dhar, D., Loomba, R., Kaufman, R. J., Saltiel, A. R., and Karin, M. (2018) ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P. Cell 175, 133-145 e115
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Oral, E. A., Reilly, S. M., Gomez, A. V., Meral, R., Butz, L., Ajluni, N., Chenevert, T. L., Korytnaya, E., Neidert, A. H., Hench, R., Rus, D., Horowitz, J. F., Poirier, B., Zhao, P., Lehmann, K., Jain, M., Yu, R., Liddle, C., Ahmadian, M., Downes, M., Evans, R. M., and Saltiel, A. R. (2017) Inhibition of IKKvarepsilon and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes. Cell Metab 26, 157-170 e157
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Shentu, T., He, M., Sun, X., Zhang, J., Zhang, F., Gongol, B., Marin, T., Zhang, J., Wen, L., Wang, Y., Geary, G., Zhu, Y., Johnson, D., Shyy, J. (2016) AMP-Activated Protein Kinase and Sirtuin 1 Coregulation of Cortactin Contributes to Endothelial Function. Arterioscler Thromb Vasc Biol 36(12):2358-2368
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Sun, X., Fu, Y., Gu, M., Zhang, L., Li, D., Li, H., Chien, S., Shyy, J. Y., and Zhu, Y. (2016) Activation of integrin alpha5 mediated by flow requires its translocation to membrane lipid rafts in vascular endothelial cells. Proc Natl Acad Sci U S A 113, 769-774
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Zhang, D., Sun, X., Liu, J., Xie, X., Cui, W., Zhu, Y. (2015) Homocysteine accelerates senescence of endothelial cells via DNA hypomethylation of human telomerase reverse transcriptase. Arterioscler Thromb Vasc Biol 35(1):71-8
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Zhao, P., Elks, C. M., and Stephens, J. M. (2014) The induction of lipocalin-2 protein expression in vivo and in vitro. J Biol Chem 289, 5960-5969
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Zhao, P., and Stephens, J. M. (2013) STAT1, NF-kappaB and ERKs play a role in the induction of lipocalin-2 expression in adipocytes. Mol Metab 2, 161-170
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Zhao, P., and Stephens, J. M. (2013) Identification of STAT target genes in adipocytes. JAKSTAT 2, e23092
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Gu, M. X.*, Fu, Y.*, Sun, X. L.*, Ding, Y. Z., Li, C. H., Pang, W., Pan, S., and Zhu, Y. (2012) Proteomic analysis of endothelial lipid rafts reveals a novel role of statins in antioxidation. J Proteome Res 11, 2365-2373. (*co-first authors)